Thematic Minireview Series on Phospholipase D and Cancer [Signal Transduction]

July 2nd, 2014 by Gomez-Cambronero, J. M., Carman, G. M.

Phospholipase D (PLD) signaling plays a critical role in cell growth and proliferation, vesicular trafficking, secretion and endocytosis. At the cellular level, PLD and its reaction product PA, interact with a large number of protein partners that are directly related to the actin cytoskeleton and cell migration. Cancer invasion and metastasis rely heavily on cellular motility and as such, they have put PLD at center stage in cancer research. This minireview series highlights some of the molecular mechanisms that evidence the emerging tumorigenic potential of PLD, the role of the microenvironment, and putative connections with inflammation. PLD represents a potential target for the rational development of therapeutics against cancer and other diseases.