Discovery and characterization of highly potent and selective allosteric USP7 inhibitors
December 4th, 2017 by Gerald Gavory
Discovery and characterization of highly potent and selective allosteric USP7 inhibitors
Discovery and characterization of highly potent and selective allosteric USP7 inhibitors, Published online: 04 December 2017; doi:10.1038/nchembio.2528
A selective inhibitor of the deubiquitinase USP7 binds an allosteric site to inhibit its MDM2-stabilizing activity, resulting in stabilization of p53 and p21, which confers hypersensitivity to cancer cells for killing by the compound.