Cell division: TIPs for shaping Aurora B activity

March 18th, 2016 by George Zachos

Nature Chemical Biology 12, 204 (2016). doi:10.1038/nchembio.2041

Author: George Zachos

Cdk1 links mitotic entry to faithful chromosome segregation by activating the acetyltransferase TIP60. Acetylation of Aurora B kinase by TIP60 protects Aurora B's activation loop from dephosphorylation by the PP2A phosphatase to ensure robust Aurora B activation.