Protein degradation: DCAFinating splicing
April 24th, 2017 by Georg E Winter
Nature Chemical Biology 13, 575 (2017). doi:10.1038/nchembio.2378
Author: Georg E Winter
Chemical control of protein homeostasis and induction of protein destabilization are emerging therapeutic strategies. Two recent studies identify a set of sulfonamides that can modulate the CRL4DCAF15 E3 ligase complex to target the splicing factor RBM39 for proteasomal degradation.
The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity
July 27th, 2014 by Georg E Winter
Nature Chemical Biology 10, 768 (2014). doi:10.1038/nchembio.1590
Authors: Georg E Winter, Branka Radic, Cristina Mayor-Ruiz, Vincent A Blomen, Claudia Trefzer, Richard K Kandasamy, Kilian V M Huber, Manuela Gridling, Doris Chen, Thorsten Klampfl, Robert Kralovics, Stefan Kubicek, Oscar Fernandez-Capetillo, Thijn R Brummelkamp & Giulio Superti-Furga