Discovery of a selective inhibitor of doublecortin like kinase 1

April 6th, 2020 by Fleur M. Ferguson

Nature Chemical Biology, Published online: 06 April 2020; doi:10.1038/s41589-020-0506-0

A highly selective inhibitor of the DCLK1/2 kinases is used to uncover the consequences of DCLK1 inhibition on viability, phosphosignaling and the transcriptome in patient-derived organoid models of pancreatic ductal adenocarcinoma.