Molecular basis for the P450-catalyzed C–N bond formation in indolactam biosynthesis
October 21st, 2019 by Fei He
Nature Chemical Biology, Published online: 21 October 2019; doi:10.1038/s41589-019-0380-9
Structural and functional analyses of two cytochrome P450 monooxygenases reveal how they catalyze C–N bond formation via a diradical mechanism and are able to accommodate a variety of substrates to form either indolactam or tricyclic products.