Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin
August 17th, 2018 by Fan Yang
Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin
Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin, Published online: 17 August 2018; doi:10.1038/s41589-018-0115-3
NMR and in vitro reconstitution indicate that GPCRs signal through SH3-containing proteins downstream of β-arrestin 1 proline regions and that arrestin allosterically activates downstream kinases by disrupting their autoinhibitory conformation.Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel
June 8th, 2015 by Fan Yang
Nature Chemical Biology 11, 518 (2015). doi:10.1038/nchembio.1835
Authors: Fan Yang, Xian Xiao, Wei Cheng, Wei Yang, Peilin Yu, Zhenzhen Song, Vladimir Yarov-Yarovoy & Jie Zheng