Designer adhesion GPCR tells its signaling story

September 28th, 2020 by Eugenia V. Gurevich

Nature Chemical Biology, Published online: 28 September 2020; doi:10.1038/s41589-020-00673-7

The ADGRL3 receptor, a member of the adhesion G-protein-coupled receptor family, is implicated in many neurological diseases. Using a novel technique involving controlled proteolysis of the receptor’s extracellular domain, this study demonstrated that ADGRL3 signals via G12/13 G proteins.