C-H activation: New recipes for biocatalysis

January 26th, 2014 by Eric M Brustad

Nature Chemical Biology 10, 170 (2014). doi:10.1038/nchembio.1457

Author: Eric M Brustad

The bacterial halogenase SyrB2 catalyzes selective installation of halogens in place of unactivated aliphatic C-H bonds. By substituting halide reagents with the nitrogenous anions N3− and NO2−, SyrB2 can perform C-N bond formation reactions not previously observed in nature.