Small Molecule Screening in Human Induced Pluripotent Stem Cell-derived Terminal Cell Types [Cell Biology]

December 20th, 2013 by Engle, S. J., Vincent, F.

A need for better clinical outcomes has heightened interest in the use of physiologically relevant human cells in the drug discovery process. Patient specific human induced pluripotent stem cells (hiPSC) may offer a relevant, robust, scalable, and cost effective model of human disease physiology. Small molecule high throughput screening (HTS) in hiPSC-derived cells with the intent of identifying novel therapeutic compounds are starting to influence the drug discovery process; however, the use of these cells presents many HTS development challenges. This technology has the potential to transform the way drug discovery is performed.