Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice
May 11th, 2020 by Elliot D. Mock
Nature Chemical Biology, Published online: 11 May 2020; doi:10.1038/s41589-020-0528-7
An inhibitor of NAPE-PLD involved in lipid biosynthesis lowers levels of the endocannabinoid anandamide and other N-acylethanolamines in cells and mouse brain and activates the hypothalamus–pituitary–adrenal axis and impaired fear extinction.