Bifunctional small molecules that mediate the degradation of extracellular proteins

August 19th, 2021 by David F. Caianiello

Nature Chemical Biology, Published online: 19 August 2021; doi:10.1038/s41589-021-00851-1

Bifunctional ‘MoDE-A’ molecules, which contain ligands that bind to an extracellular protein and carbohydrate residues that recruit it to the asialoglycoprotein receptor, mediate cellular uptake and lysosomal turnover of target proteins.
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