Structural basis for selectivity in a highly reducing type II polyketide synthase
May 4th, 2020 by Danyao Du
Nature Chemical Biology, Published online: 04 May 2020; doi:10.1038/s41589-020-0530-0
Structures of the ketosynthase–chain length factor complex from ishigamide biosynthesis, cross-linked to the acyl carrier protein, reveal the molecular interactions between these domains and how the reaction pocket limits rounds of product extension.