Metabolism: ‘Channeling’ Hans Krebs

February 17th, 2015 by Danielle Tullman-Ercek

Nature Chemical Biology 11, 180 (2015). doi:10.1038/nchembio.1758

Author: Danielle Tullman-Ercek

The physical arrangement of enzymes within native metabolic pathways is emerging as an important but underexplored area of molecular biology. Recent advances in mass spectrometry enabled confirmation of the proposal that the Krebs cycle enzymes form a complex and suggest that substrate channeling is the most likely benefit to this structural arrangement.