A topological switch in CFTR modulates channel activity and sensitivity to unfolding

August 2nd, 2021 by Daniel Scholl

Nature Chemical Biology, Published online: 02 August 2021; doi:10.1038/s41589-021-00844-0

The cystic fibrosis transmembrane conductance regulator anion channel can adopt an alternate conformation of its nucleotide-binding domain, which affects channel activity and, under certain conditions, leads to unfolding and protein degradation.
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