Chromatin biology: Breaking into the PRC2 cage

January 30th, 2017 by Daniel Holoch

Nature Chemical Biology 13, 345 (2017). doi:10.1038/nchembio.2313

Authors: Daniel Holoch & Raphaël Margueron

New small-molecule inhibitors of the histone methyltransferase PRC2 interfere with the allosteric activation of enzymatic activity. These compounds are effective against PRC2-dependent tumors that are resistant to catalytic inhibitors and provide important new tools for altering chromatin regulation.