HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain

July 22nd, 2021 by Daniel B. Grabarczyk

Nature Chemical Biology, Published online: 22 July 2021; doi:10.1038/s41589-021-00831-5

The full-length structure of HUWE1 reveals the bipartite organization of a giant E3 ubiquitin ligase, comprising a catalytic HECT domain and a large, ring-shaped scaffold that provides docking sites for various substrates and regulates E3 activity.
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