Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2
October 20th, 2020 by Colton J. Bracken
Nature Chemical Biology, Published online: 20 October 2020; doi:10.1038/s41589-020-00679-1
A screening approach finds VH-domain antibodies that bind the SARS-CoV-2 Spike protein receptor-binding domain at its interface with host ACE2. Bi-paratopic and multivalent binders have high affinity and potency.