A PTCH1 Homolog Transcriptionally Activated by p53 Suppresses Hedgehog Signaling [Cell Biology]

October 8th, 2014 by Chung, J. H., Larsen, A. R., Chen, E., Bunz, F.

The p53-mediated responses to DNA damage and the Hedgehog (Hh) signaling pathway are each recurrently dysregulated in many types of human cancer. Here we describe PTCH53, a p53 target gene that is homologous to the tumor suppressor gene PTCH1 and can function as a repressor of Hh pathway activation. PTCH53 was highly responsive to p53 in vitro, and was among a small number of genes that were consistently expressed at reduced levels in diverse TP53-mutant cell lines and human tumors. Increased expression of PTCH53 inhibited canonical Hh signaling by the G protein-coupled receptor SMO. PTCH53 thus delineates a novel, inducible pathway by which p53 can repress tumorigenic Hh signals.