Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly
March 15th, 2021 by Christopher F. Bennett
Nature Chemical Biology, Published online: 15 March 2021; doi:10.1038/s41589-021-00772-z
A chemical screen identifies DHODH inhibitors as robust activators of mitochondrial respirasome assembly. Lipidomics reveal that peroxisomal-derived ether phospholipids accumulate in mitochondria during nucleotide deprivation to drive proliferation.