Redox biology: Signaling via a peroxiredoxin sensor

December 17th, 2014 by Christine C Winterbourn

Nature Chemical Biology 11, 5 (2015). doi:10.1038/nchembio.1722

Authors: Christine C Winterbourn & Mark B Hampton

Hydrogen peroxide regulates cell signaling pathways through oxidation of specific thiol proteins. A new study describes a relay system involving peroxiredoxin 2 as a peroxide sensor that oxidizes the mammalian transcription factor STAT3 via a mixed disulfide intermediate.