Drug discovery: Tools and rules for macrocycles

July 20th, 2014 by Christian Heinis

Nature Chemical Biology 10, 696 (2014). doi:10.1038/nchembio.1605

Author: Christian Heinis

The application of macrocycles to previously undruggable targets has aroused a great deal of interest in this structural class. Recent studies advance our understanding of the way macrocycles bind protein targets and provide new strategies and tools to generate peptide-based macrocycles.