Cancer metabolism: Addicted to serine
May 18th, 2016 by Christian Frezza
Nature Chemical Biology 12, 389 (2016). doi:10.1038/nchembio.2086
Author: Christian Frezza
Phosphoglycerate dehydrogenase (PHGDH) is an enzyme of serine biosynthesis overexpressed in various types of cancer. A new series of PHGDH inhibitors selectively block proliferation of PHGDH-dependent cancer cells and reveal an unexpected role of serine biosynthesis in coordinating one-carbon metabolism.