Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo
May 10th, 2021 by Christian Dubiella
Nature Chemical Biology, Published online: 10 May 2021; doi:10.1038/s41589-021-00786-7
The development of Sulfopin, a highly selective and potent, covalent Pin1 inhibitor that phenocopies Pin1 knockout and regresses tumors in murine and zebrafish models of neuroblastoma as well as in a pancreatic cancer mouse model.