CueR activates transcription through a DNA distortion mechanism

September 28th, 2020 by Chengli Fang

Nature Chemical Biology, Published online: 28 September 2020; doi:10.1038/s41589-020-00653-x

Structural analysis of transcription activation complex comprising E. coli transcription factor CueR, RNAP holoenzyme and promoter DNA reveals that CueR distorts the DNA conformation to promote the association of promoter with polymerase.