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Assembly and clustering of natural antibiotics guides target identification

February 1st, 2016 by Chad W Johnston

Nature Chemical Biology 12, 233 (2016). doi:10.1038/nchembio.2018

Authors: Chad W Johnston, Michael A Skinnider, Chris A Dejong, Philip N Rees, Gregory M Chen, Chelsea G Walker, Shawn French, Eric D Brown, János Bérdy, Dennis Y Liu & Nathan A Magarvey

  • Posted in Nat Chem Biol, Publications
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Natural products: Untwisting the antibiotic’ome

February 17th, 2015 by Chad W Johnston

Nature Chemical Biology 11, 177 (2015). doi:10.1038/nchembio.1757

Authors: Chad W Johnston & Nathan A Magarvey

Microbial natural products and the specific subset with antibiotic activity, 'the antibiotic'ome', consist of a dizzying array of structures and exert their effects by many known modes of action. In this issue, Cociancich et al. describe a unique natural product that—along with a compound identified in a recent publication by Baumann et al.—defines a new antibacterial chemical scaffold that acts on a rarely hit target, DNA gyrase subunit A.