<span class=”small-caps”>d</span>-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition
March 16th, 2020 by Cesira de Chiara
Nature Chemical Biology, Published online: 16 March 2020; doi:10.1038/s41589-020-0498-9
d-Cycloserine inactivates alanine racemase by forming an adduct with the pyridoxal 5′-phosphate cofactor, but structural and spectroscopic analyses reveal that reactivation occurs on adduct hydrolysis and product rearrangement to a stable oxime.