A lipid site shapes the agonist response of a pentameric ligand-gated ion channel
October 7th, 2019 by Camille M. Hénault
Nature Chemical Biology, Published online: 07 October 2019; doi:10.1038/s41589-019-0369-4
A crystal structure of prokaryotic pentameric ligand-gated ion channel ELIC reveals a lipid-binding site at the interface between subunits that is shaped by a flexible helix important for channel desensitization upon lipid binding.