CRISPR-Cas9 screens identify regulators of antibody–drug conjugate toxicity
August 26th, 2019 by C. Kimberly Tsui
Nature Chemical Biology, Published online: 26 August 2019; doi:10.1038/s41589-019-0342-2
A series of genome-wide and targeted CRISPR screens uncovered regulators of antibody–drug conjugate (ADC) toxicity. Depletion of sialic acids was found to enhance ADC lysosomal delivery, in part by reducing ADC recycling.