PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase
September 28th, 2020 by Bikash Adhikari
Nature Chemical Biology, Published online: 28 September 2020; doi:10.1038/s41589-020-00652-y
A bifunctional AURORA-A degrader induces the fast and specific degradation of this kinase in cancer cell lines, which enables targeting of non-catalytic, oncogenic functions of AURORA-A resulting in S-phase arrest and rampant apoptosis.