Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth
June 29th, 2021 by Bianca J. Lee
Nature Chemical Biology, Published online: 29 June 2021; doi:10.1038/s41589-021-00843-1
Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growthSelective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth
June 24th, 2021 by Bianca J. Lee
Nature Chemical Biology, Published online: 24 June 2021; doi:10.1038/s41589-021-00813-7
Design of a bivalent inhibitor containing an ATP-competitive moiety and rapamycin-modified FRB binding ligand that selectively inhibits mTORC1 results in potent and durable inhibition of 4EBP1 phosphorylation and cell proliferation in vitro and in vivo.