Identification of a potent and selective covalent Pin1 inhibitor

June 1st, 2020 by Benika J. Pinch

Nature Chemical Biology, Published online: 01 June 2020; doi:10.1038/s41589-020-0550-9

A highly selective covalent peptide inhibitor of the peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) is used to show that Pin1 cooperates with mutant KRAS to promote pancreatic ductal adenocarcinoma (PDAC) transformation.