Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein
April 23rd, 2018 by Ben E. Clifton
Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein
Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein, Published online: 23 April 2018; doi:10.1038/s41589-018-0043-2
Ancestral protein reconstruction, with structural and biochemical analysis, illustrates the evolution of a solute-binding protein to cyclohexadienyl dehydratase through incorporation of a catalytic residue and gradual reshaping of the binding site.