Discovery of a first-in-class EZH2 selective degrader

December 9th, 2019 by Anqi Ma

Nature Chemical Biology, Published online: 09 December 2019; doi:10.1038/s41589-019-0421-4

A hydrophobic tagging method is used to develop a selective degrader for the chromatin regulator EZH2, which inhibits proliferation of triple-negative breast cancer cell lines in vitro and in vivo.