Targeting transcription is no longer a quixotic quest
November 17th, 2015 by Anna K Mapp
Nature Chemical Biology 11, 891 (2015). doi:10.1038/nchembio.1962
Authors: Anna K Mapp, Rachel Pricer & Steven Sturlis
Misregulated transcription factors play prominent roles in human disease, but their dynamic protein-protein interaction network has long made the goal of transcription-targeted therapeutics impractical. Recent advances in technologies for modulating protein interaction networks mean that the end of the quest is in sight.