Carbohydrates: A phenol sandwich fights diabetes

August 18th, 2015 by Anna Bernardi

Nature Chemical Biology 11, 635 (2015). doi:10.1038/nchembio.1888

Authors: Anna Bernardi & Sara Sattin

The complex flavonoid montbretin A (MbA) is a powerful inhibitor of human pancreatic amylase (HPA) and a potential tool in the treatment of type 2 diabetes. The X-ray structure of the MbA–HPA complex now shows that a hydrophobic collapse of two phenol fragments in the structure of MbA is key to its activity.