Facile target validation in an animal model with intracellularly expressed monobodies
July 16th, 2018 by Ankit Gupta
Facile target validation in an animal model with intracellularly expressed monobodies
Facile target validation in an animal model with intracellularly expressed monobodies, Published online: 16 July 2018; doi:10.1038/s41589-018-0099-z
The development of a selective and potent monobody to WDR5, a component of the mixed linear leukemia methyltransferase complex, as genetically encoded inhibitor enables suppression of leukemogenesis and confers survival in a mouse leukemia model.