Probing the epigenome

July 21st, 2015 by Andrea Huston

Nature Chemical Biology 11, 542 (2015). doi:10.1038/nchembio.1871

Authors: Andrea Huston, Cheryl H Arrowsmith, Stefan Knapp & Matthieu Schapira

Epigenetic chemical probes are having a strong impact in biological discovery and target validation. Systematic coverage of emerging epigenetic target classes with these potent, selective, cell-active chemical tools will profoundly influence understanding of the human biology and pathology of chromatin-templated mechanisms.