Guided nuclear exploration increases CTCF target search efficiency

December 2nd, 2019 by Anders S. Hansen

Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0422-3

Single-particle tracking and mathematical modeling methods reveal the searching mechanism of CTCF for its cognate sites on DNA. An RNA-binding region in CTCF mediates its trapping in small zones and increases its target search efficiency.