Mining for mouth metabolites

March 25th, 2021 by Amber M. Scharnow

Nature Chemical Biology, Published online: 25 March 2021; doi:10.1038/s41589-021-00784-9

Genome mining of Streptococcus mutans clinical samples led to the identification of a structurally unique polyketide/non-ribosomal peptide, mutanofactin-697, that promotes biofilm formation. This study highlights the unexplored functional potential of secondary metabolites and opens new avenues for inhibiting pathogenic processes.