Chemical probes: The many genes of drug mechanism

January 19th, 2016 by Adam C Palmer

Nature Chemical Biology 12, 57 (2016). doi:10.1038/nchembio.2010

Author: Adam C Palmer

A small molecule's biological activity in a cell depends on the actions of many gene products. Correlations between basal gene expression and compound sensitivity across hundreds of human cell lines reveal a broad view of cellular mechanisms of action.